NIS mediated uptake of iodide ion into follicular cells of the thyroid gland is initial stage for thyroid hormone biosynthesis ... Gupta, M.K., Misra, K. Modeling and simulation analysis of propyl-thiouracil (PTU), an anti-thyroid drug on thyroid peroxidase (TPO), thyroid stimulating hormone receptor (TSHR), and sodium iodide (NIS) symporter based on systems biology approach. Publication Date: Tue Oct 31 00:00:00 EST 1950 Research Org. It was first pointed out by the Mackenzies and. Addition of 0.1 per cent, thiouracil or thiourea to the diet of white Plymouth Bock chicks up to 14 days old, caused increased thyroid weight, the degree of enlargement being greater in females, than in males. thiouracil: (thī′ō-yo͝or′ə-sĭl′) n. A white crystalline compound, C 4 H 4 N 2 OS, that interferes with the synthesis of thyroxine, used to reduce the action of the thyroid gland… To incorporate these facts into the current concept of thyrotropic exophthalmos one must conclude that the moderately overactive thyroid gland is less capable of inactivating thyrotropin than is the gland completely blocked but hyper- trophic and hyperplastic under the influence of propyi thiouracil. A multinodular goiter contains multiple distinct nodules within the goiter, but its cause is less clear. gland. [Article in German] GITSCH E, REITINGER J. Answer: (c) 9. The selective uptake of 14C- and ‘251-thiouracil in mela- nomas depends on their acceptance as false melanin precur- sors, making them specific markers for growing melanin. My saved folders . Groups of tubules traversed the width of the gland occasionally, al though they were more frequent at the periphery. The term goiter is used to describe any enlargement of the thyroid gland, which can be caused by iodine deficiency or a thyroid disorder. Structural changes in the thyroid gland of buffalo following administration of thiouracil. 20 March 2020. thiouracil. Certain special histological features of thyroid hyperplasia in the monkey are described in this report. thiouracil synonyms, thiouracil pronunciation, thiouracil translation, English dictionary definition of thiouracil. Facebook; Twitter; Related Content . Similar reports have been made on the production of thyroid adenomas by either thiourea or thiouracil without the presence of … CARPEN E, CARPEN I, TEIR H. Acta Endocrinol (Copenh), 22(4):395-406, 01 Aug 1956 Cited by: 0 articles | PMID: 13354230 The changes in weight and morphology of the thyroid gland and hypophysis following chronic administration of thiouracil in the diet have been described. The results indicate that radiolabeled thiouracil may be use- ful for clinical diagnosis and, possibly, therapy of malignant melanotic melanomas.] The thyroid gland is an endocrine gland in your neck. [Pregnancy and thiouracil adenoma of the thyroid gland]. 1. Through secretion of triiodothyronine (T3) and thyroxine (T4), the thyroid Exocrine glands use ducts to excrete substances. thiouracil: translation. This thyroid hyperplasia, which is considered to be compensatory to the failure of thyroid hormone synthesis, is abolished by feeding thyroid powder or by hypophy-sectomy (Astwood, … Define thiouracil. The isthmus usually overlies the region from the 2nd to 4th tracheal cartilage. Share This Article: Copy. Glands come in endocrine and exocrine varieties. 6.33): i. Iodide trapping that is the uptake of iodide by the follicular cells from the plasma against the electrochemical gradient. If a glass be present, it must have been fluid at the temperature of the run, for the glass conforms to the bottom of the chamber and has a flat surface which is substantially horizontal. It was the object of this investigation to determine whether the endocrine function of the human thyroid gland could be inhibited by these compounds and to obtain information concerning their dosage and toxicity in individuals with normal thyroid glands and in cases of hyperthyroidism. References. ADELE BISSELL 1 From the … By feeding dl-thyroxine with thiouracil, the thyroid weight was decreased. It makes two hormones that are secreted into the blood: thyroxine (T4) and triiodothyronine (T3). E. B. ASTWOOD, E. B. ASTWOOD 1 From the Departments of Medicine and Pharmacology, Harvard Medical School and the Medical Clinic of the Peter Bent Brigham Hospital BOSTON, MASSACHUSETTS. Authors: Lees, J; Alexander, W D; Marchant, B Publication Date: Sun Jul 01 00:00:00 EDT 1973 Research Org. OSTI.GOV Technical Report: The Effect of Thiouracil on the Uptake of Radioactive Iodine by the Thyroid Gland of Summer Frogs (Rana pipiens) The Effect of Thiouracil on the Uptake of Radioactive Iodine by the Thyroid Gland of Summer Frogs (Rana pipiens) Full Record; Other Related Research; Authors: Matthews, S.A. Analysis of the data has shown that a progressive increase in weight of both organs was limited to the female rats. The following diagram indicates the action of TSH on thyroid gland (Fig. In chronically deficient patients, this abnormality is directly related to the enlargement of the thyroid gland (a) Impaired conversion of T3 and T4 (b) Reduced activity of thyroperoxidase (c) Elevated levels of TSH (d) An antibody that binds to the TSH receptor in the thyroid gland. Title: The Effects of Thiouracil on the Thyroid Gland of Triturus Viridescens: Authors: Marshall, Jr., Jerome Benjamin: Department: Biology: Class Year: Vol 367, Issue 6484. ). 1955;144(3):288-94. The thyroid gland plays an important physiological role in the body. Save to my folders. It weighs about 15- 20g. The effect of thiouracil on the uptake of radioactive iodine by the thyroid gland of summer frogs (rana pipiens). EFFECT OF THIOURACIL ON THE IODINE CONTENT OF THE THYROID GLAND 1. The thyroid gland is located immediately below the larynx and anterior to the upper part of the trachea. Effects of intraperitoneal injections of thyroid gland suspensions and oral methyl thiouracil administration in rats. Z Geburtshilfe Gynakol. Thyroid cancer. Short epithelial buds projecting slightly into the lumen were not infrequent. Activity of monoamine oxidase in the thyroid gland of the rat after thiouracil feeding. The rather thorough destruction of the thyroid gland by injection of experimental animals with large doses of radioiodine has been demonstrated by Reinhardt (37), Leblond (28), Chapman (9), Findlay and Leblond (13), Gorbman (18), Chaikoff and Taurog (8), Freedberg and Kurland (14), Winchester, Comar, and Davis (46), Shapiro (41), and Rugh (38, 39). The thyroid gland works primarily by absorbing iodine from our diets and then using it to make thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroid gland and thyroprotein or thiouracil The administration of certain sulfonamides or thiourea results in an enlarged, hyperemic, and hyperplastic thyroid gland coincident with the state of hypothyroidism. n. A white crystalline compound, C4H4N2OS, that interferes with the synthesis of thyroxine, used to reduce the action of the thyroid gland, especially in... Thiouracil - definition of thiouracil by The Free Dictionary. Thiouracil definition is - a bitter crystalline compound C4H4N2OS that depresses the function of the thyroid gland. Since the thyroid gland functions by releasing hormones directly into the bloodstream, it is considered a key part of our endocrine system. may also contain an amorphous precipitate, or one of these with a glass. The effect of thyroid and thiouracil on the natural resistance of mice to infection with Hymenolepis. The time required for the maximal enlargement per 100 g. bodyweight waa 12 days. noun. Google Scholar. HOPSU VK, KARINKANTA H. Annales Medicinae Experimentalis et Biologiae Fenniae, 01 Jan 1962, 40: 1-7 PMID: 14448829 . Effect of Diethylstilbestrol on the Thyroid Glands of Chicks Receiving Thiouracil. Thyroid disorders are very common and tend mainly to occur in women, although anybody - men, teenagers, children and babies, too - can be affected. Invest Drrmato! About the same time, Bielschowsky re- ported the presence of both benign and ma- lignant tumors in the thyroid glands ofrats fed 2-acetylaminofluorene and ally1 thiourea. depresses the function of the thyroid gland (Freq. thiouracil — noun Etymology: International Scientific Vocabulary Date: 1905 a bitter crystalline compound C4H4N2OS that depresses the function of the thyroid gland … New Collegiate Dictionary Pharm. a white, slightly water soluble, bitter, crystalline powder C4H4N2OS, used chiefly in treating hyperthyroidism by reducing the activity of the thyroid gland. Thyroid hormone production is also seasonal in nature with concentrations being highest during the winter months and lowest during the long days of summer (Karsch et al., 1995; Souza et al., 2002). extent the thyroid. ADELE BISSELL. The hormone TSH secreted by the anterior pituitary gland affects this step. The chances that a nodule is cancerous are small. ADMINISTRATION of thiouracil to rhesus monkeys (Macaca mulatta) causes hyperplasia and colloid depletion in monkeys as it does in other animals and in man. Author J E LARSH Jr. PMID: 20340896 No abstract available. These hormones are necessary for all the cells in your body to work normally. Thiouracil is a sulfur-containing uracil.An established antithyroid drug and highly selective inhibitor of nitric oxide synthase (NOS), thiouracil also covalently binds to dopaquinone, produced by tyrosinase catalyzed oxidation of tyrosine, thereby selectively accumulating in de novo-synthesized melanin in overactive melanin-producing cells and providing a means to localize melanoma cells. 1947 Dec;33(2):24. thiouracil: A white crystalline compound, C 4 H 4 N 2 OS, that interferes with the synthesis of thyroxine, used to reduce the action of the thyroid gland, especially in the treatment of hyperthyroidism. THYROID GLAND OF RATS TREATED WITH THIOURACIL By JOYCE E. SANTLER From the Department of Anatomy and Embryology, University College, London (Received 27 October 1956) SUMMARY The effect ofthiouracil administration on thenumbers follicular and stromal cells in thyroid gland of the male albino rat was investigated. There was evidence of involution of the thyroid gland in male rats which had received the diet for 10 months. Get this from a library! Stay Connected to Science. [Samuel Arthur Matthews; … Mackenzie, J. The effect of thyroid and thiouracil on the natural resistance of mice to infection with Hymenolepis J Parasitol. LAQ1JEUR—Hyperplasia of Thyroid Glands and Thiouracil 9249 The nuclei of the epithelial cells were more com pact and smaller than in the remaining @g1and. Thyroid gland The thyroid gland is one of the largest endocrine glands. It consists of 2 lateral lobes connected by a narrow band of thyroid tissue called the isthmus. Prakash P, Sharma D. The effects of a goitrogen (thiouracil) on the structural variations of the thyroid gland were studied in male buffalo calves. 1. By JEAN E. SELLE, RAYMOND M. SELLE. There is a question whether thiouracil has a deleterious effect on blood vessels not only in the thyroid gland but systemically, as is seen occasionally in the use of thiocyanate preparations in the treatment of indicated types of hypertension. Search for other works by this author on: Oxford Academic. Science 16 Apr 1948: 394-395 . Similar Articles in: Citing Articles in: Read the Latest Issue of Science. 6.32): The steps in the biosynthesis of the hormone are (Fig. G. bodyweight waa 12 days were more frequent at the periphery monkey are described in this.! An important physiological role in the thyroid gland of summer frogs ( rana pipiens ) pipiens ) is cancerous small!: 1-7 PMID: 14448829 for the maximal enlargement per 100 g. bodyweight 12. 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